Section: New Results

Analysis of results from clinical trials and cohorts in other fields (Epidemiology, Medical Sciences, Neuroimaging, Sport Sciences)

• Zago L, Hervé PY, Genuer R, Laurent A, Mazoyer B, Tzourio-Mazoyer N, Joliot M. Predicting hemispheric dominance for language production in healthy individuals using support vector machine. Hum Brain Mapp. 2017 Dec;38(12):5871-5889. doi: 10.1002/hbm.23770. [34]

  Joint work with the GIN-IMN team, application of a variable selection procedure based on SVM method to analyze functional MRI data.

• Tabue-Teguo M, Grasset L, Avila-Funes JA, Genuer R, Proust-Lima C, Péres K, Féart C, Amieva H, Harmand MG, Helmer C, Salles N, Rainfray M, Dartigues JF. Prevalence and Co-Occurrence of Geriatric Syndromes in People Aged 75 Years and Older in France: Results From the Bordeaux Three-city Study. J Gerontol A Biol Sci Med Sci. (2017) [31]

  Application of Multiple Correspondence Analysis which enlights frailty and dependent profile of people from the Three-city study.

• Née M, Avalos M, Luxcey A, Contrand B, Salmi LR, Fourrier-Réglat A, Gadegbeku B, Lagarde E, Orriols L. Prescription medicine use by pedestrians and the risk of injurious road traffic crashes: A case-crossover study. PLoS Medicine. Jul 18;14(7):e1002347 (2017) [24]

  Exploration of the association between the use of medicinal drugs and the risk of being involved in a road traffic crash as a pedestrian. We applied the Lasso methodology that we previously developed for the case-crossover design in a high-dimensional setting. This design controls for time-invariant factors by using each case as its own control. This study highlights the necessity of improving awareness of the effect of medicines on pedestrians.

• Hellard P, Scordia C, Avalos M, Mujika I, Pyne DB. Modelling of optimal training load patterns during the 11 weeks preceding major competition in elite swimmers. Applied Physiology, Nutrition, and Metabolism. Jun 26 (2017) [20]

  Quantification of the relationships between the effects of periodization variables and competitive performance in elite swimmers using semiparametric mixed effects models. In the framework of the 2014-2016 R&D project "Quels schémas de périodisation pour la préparation des Jeux Olympiques à Rio ?" with the French Swimming Federation.

• Hejblum BP, Cui J, Lahey LJ, Cagan A, Sparks JA, Sokolove J, Cai T, Liao KP, Association between anti-citrullinated fibrinogen antibodies and coronary artery disease in rheumatoid arthritis, Arthritis Care & Research, in press, 2017. [19].

  We show that anti-cit-fibrinogen antibodies as a group were associated with CAD outcomes in our RA cohort, with the strongest signal for association arising from a subset of the autoantibodies.

• Liao KP, Sparks JA, Hejblum BP, Kuo IH, Cui J, Lahey LJ, Cagan A, Gainer VS, Liu W, Cai TT, Sokolove J, Cai T, Phenome-wide association study of autoantibodies to citrullinated and non-citrullinated epitopes in rheumatoid arthritis, Arthritis & Rheumatology, 69: 742–749, 2017. [22]

  We demonstrated application of a bioinformatics method, the PheWAS, to screen for the clinical significance of RA-related autoantibodies. Using the PheWAS approach, we identified potentially significant links between variations in the levels of autoantibodies and comorbidities of interest in RA.